Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10

Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous. In this study, we provide evidence that Sonic hedgehog (Shh), but neither Desert hedgehog (Dhh) nor Indian hedgehog (Ihh), is the main protein w...

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Autores principales: Zhou, Xiangyu, Liu, Zhiqiang, Jang, Feng, Xiang, Chuannan, Li, Yuan, He, Yanzheng
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431299/
https://ncbi.nlm.nih.gov/pubmed/22956998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044121
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