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Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation

BACKGROUND: Mutations in the LMNA gene encoding A-type nuclear lamins can cause dilated cardiomyopathy with or without skeletal muscular dystrophy. Previous studies have shown abnormally increased extracellular signal-regulated kinase 1/2 activity in hearts of Lmna(H222P/H222P) mice, a small animal...

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Bibliografiset tiedot
Päätekijät: Muchir, Antoine, Wu, Wei, Sera, Fusako, Homma, Shunichi, Worman, Howard J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185249/
https://ncbi.nlm.nih.gov/pubmed/25218145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.09.020
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