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Constitutive Expression of HIF-α Plays a Major Role in Generation of Clear Cell Phenotype in Human Primary and Metastatic Renal Carcinoma
The extensive lipid accumulation occurred in clear cell renal cell carcinoma (ccRCC) resulted in a clear cell cytoplasm. Hypoxia inducible factor alpha (HIF-α) was constitutively expressed in many ccRCC and transcriptionally regulates greater than one hundred genes. In a recent breakthrough study, H...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4184929/ https://ncbi.nlm.nih.gov/pubmed/25046225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000012 |
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