Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans

The anticoagulant warfarin has >30 million prescriptions per year in the United States. Doses can vary 20-fold between patients, and incorrect dosing can result in serious adverse events. Variation in warfarin pharmacokinetic and pharmacodynamic genes, such as CYP2C9 and VKORC1, do not fully expl...

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Main Authors: Daneshjou, Roxana, Gamazon, Eric R., Burkley, Ben, Cavallari, Larisa H., Johnson, Julie A., Klein, Teri E., Limdi, Nita, Hillenmeyer, Sara, Percha, Bethany, Karczewski, Konrad J., Langaee, Taimour, Patel, Shitalben R., Bustamante, Carlos D., Altman, Russ B., Perera, Minoli A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Thrombosis and Hemostasis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183989/
https://ncbi.nlm.nih.gov/pubmed/25079360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-568436
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