Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma

BACKGROUND: Melphalan is one of the most active chemotherapeutic agents in the treatment of multiple myeloma (MM). However, the mechanism underlying differential patient responses to melphalan therapy is unknown. METHODS: Chromatin structure, transcriptional activity and DNA damage response signals...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gkotzamanidou, M, Sfikakis, P P, Kyrtopoulos, S A, Bamia, C, Dimopoulos, M A, Souliotis, V L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Clinical Study
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183844/
https://ncbi.nlm.nih.gov/pubmed/25051404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.410
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