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Dissection of Structural and Functional Requirements That Underlie the Interaction of ERdj3 Protein with Substrates in the Endoplasmic Reticulum

ERdj3, a mammalian endoplasmic reticulum (ER) Hsp40/DnaJ family member, binds unfolded proteins, transfers them to BiP, and concomitantly stimulates BiP ATPase activity. However, the requirements for ERdj3 binding to and release from substrates in cells are not well understood. We found that ERdj3 h...

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Bibliografiske detaljer
Main Authors: Otero, Joel H., Lizák, Beata, Feige, Matthias J., Hendershot, Linda M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183791/
https://ncbi.nlm.nih.gov/pubmed/25143379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587147
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