Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase

[Image: see text] Electrostatic interactions play an important role in enzyme catalysis by guiding ligand binding and facilitating chemical reactions. These electrostatic interactions are modulated by conformational changes occurring over the catalytic cycle. Herein, the changes in active site elect...

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Päätekijät: Liu, C. Tony, Layfield, Joshua P., Stewart, Robert J., French, Jarrod B., Hanoian, Philip, Asbury, John B., Hammes-Schiffer, Sharon, Benkovic, Stephen J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183630/
https://ncbi.nlm.nih.gov/pubmed/24977791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5038947
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