Загрузка...
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
The recent success of antibody–drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the...
Сохранить в:
| Главные авторы: | , , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183314/ https://ncbi.nlm.nih.gov/pubmed/25114240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408124111 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|