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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
The auristatin class of microtubule destabilizers are highly potent cytotoxic agents against several cancer cell types when delivered as antibody drug conjugates. Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define th...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4982639/ https://ncbi.nlm.nih.gov/pubmed/27518442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160890 |
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