Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries.

A technique is described for the simultaneous and controlled random mutation of all three heavy or light chain complementarity-determining regions (CDRs) in a single-chain Fv specific for the O polysaccharide of Salmonella serogroup B. Sense oligonucleotides were synthesized such that the central ba...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Deng, S J, MacKenzie, C R, Hirama, T, Brousseau, R, Lowary, T L, Young, N M, Bundle, D R, Narang, S A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41833/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7539139/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.4992
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