Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries.
A technique is described for the simultaneous and controlled random mutation of all three heavy or light chain complementarity-determining regions (CDRs) in a single-chain Fv specific for the O polysaccharide of Salmonella serogroup B. Sense oligonucleotides were synthesized such that the central ba...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41833/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7539139/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.4992 |
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