Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries.

A technique is described for the simultaneous and controlled random mutation of all three heavy or light chain complementarity-determining regions (CDRs) in a single-chain Fv specific for the O polysaccharide of Salmonella serogroup B. Sense oligonucleotides were synthesized such that the central ba...

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Detalhes bibliográficos
Main Authors: Deng, S J, MacKenzie, C R, Hirama, T, Brousseau, R, Lowary, T L, Young, N M, Bundle, D R, Narang, S A
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41833/
https://ncbi.nlm.nih.gov/pubmed/7539139
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