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Role of cavities and hydration in the pressure unfolding of T(4) lysozyme

It is well known that high hydrostatic pressures can induce the unfolding of proteins. The physical underpinnings of this phenomenon have been investigated extensively but remain controversial. Changes in solvation energetics have been commonly proposed as a driving force for pressure-induced unfold...

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Autors principals: Nucci, Nathaniel V., Fuglestad, Brian, Athanasoula, Evangelia A., Wand, A. Joshua
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183293/
https://ncbi.nlm.nih.gov/pubmed/25201963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410655111
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