Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways

BACKGROUND: The novel small molecule R118 and the biguanide metformin, a first-line therapy for type 2 diabetes (T2D), both activate the critical cellular energy sensor 5′-AMP-activated protein kinase (AMPK) via modulation of mitochondrial complex I activity. Activation of AMPK results in both acute...

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Main Authors: Jenkins, Yonchu, Sun, Tian-Qiang, Li, Yingwu, Markovtsov, Vadim, Uy, Gerald, Gross, Lisa, Goff, Dane A, Shaw, Simon J, Boralsky, Luke, Singh, Rajinder, Payan, Donald G, Hitoshi, Yasumichi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182811/
https://ncbi.nlm.nih.gov/pubmed/25252968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-674
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