AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes

Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of nutrient uptake and catabolism for mitochondrial ATP generation to restor...

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Detalhes bibliográficos
Main Authors: Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L., Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J., McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J., Xu, Xiang, Issakani, Sarkiz D., Carroll, David C., Goff, Dane A., Shaw, Simon J., Singh, Rajinder, Boros, Laszlo G., Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G., Kinsella, Todd M., Hitoshi, Yasumichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855387/
https://ncbi.nlm.nih.gov/pubmed/24339975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081870
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