Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells

mTOR complex 1 (mTORC1) and p70 S6 kinase (S6K1) are both involved in the development of obesity-linked insulin resistance. Recently, we showed that the S6K1 inhibitor PF-4708671 (PF) increases insulin sensitivity. However, we also reported that PF can increase glucose metabolism even in the absence...

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Udgivet i:J Biol Chem
Main Authors: Shum, Michael, Houde, Vanessa P., Bellemare, Vicky, Junges Moreira, Rafael, Bellmann, Kerstin, St-Pierre, Philippe, Viollet, Benoit, Foretz, Marc, Marette, André
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690709/
https://ncbi.nlm.nih.gov/pubmed/31243102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008488
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