Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the carbohydrate-response element–binding protein through raised cellular intermediates of glucose metabolism. In this study we determined the candidate mechanisms by which metformin...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Moonira, Tabassum, Chachra, Shruti S., Ford, Brian E., Marin, Silvia, Alshawi, Ahmed, Adam-Primus, Natasha S., Arden, Catherine, Al-Oanzi, Ziad H., Foretz, Marc, Viollet, Benoit, Cascante, Marta, Agius, Loranne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062158/
https://ncbi.nlm.nih.gov/pubmed/31974165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012533
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