Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the carbohydrate-response element–binding protein through raised cellular intermediates of glucose metabolism. In this study we determined the candidate mechanisms by which metformin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Moonira, Tabassum, Chachra, Shruti S., Ford, Brian E., Marin, Silvia, Alshawi, Ahmed, Adam-Primus, Natasha S., Arden, Catherine, Al-Oanzi, Ziad H., Foretz, Marc, Viollet, Benoit, Cascante, Marta, Agius, Loranne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062158/
https://ncbi.nlm.nih.gov/pubmed/31974165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012533
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