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A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion
Two structurally related protein kinase families, the Rho kinases (ROCK) and themyotonic dystrophy kinase-related Cdc42-binding kinases (MRCK) are required for migration and invasion of cancer cells. We hypothesized that simultaneous targeting of these two kinase families might represent a novel the...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4182185/ https://ncbi.nlm.nih.gov/pubmed/25172415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.08.032 |
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