A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

Two structurally related protein kinase families, the Rho kinases (ROCK) and themyotonic dystrophy kinase-related Cdc42-binding kinases (MRCK) are required for migration and invasion of cancer cells. We hypothesized that simultaneous targeting of these two kinase families might represent a novel the...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Kale, Vijay Pralhad, Hengst, Jeremy A., Desai, Dhimant H., Dick, Taryn E., Choe, Katherine N., Colledge, Ashley L., Takahashi, Yoshinori, Sung, Shen-Shu, Amin, Shantu G., Yun, Jong K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182185/
https://ncbi.nlm.nih.gov/pubmed/25172415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.08.032
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla