Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas

BACKGROUND: Mismatch repair deficient colorectal adenomas are composed of transformed cells that descend from a common founder and progressively accumulate genomic alterations. The proliferation history of these tumors is still largely unknown. Here we present a novel approach to rebuild the prolife...

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Main Authors: De Grassi, Anna, Iannelli, Fabio, Cereda, Matteo, Volorio, Sara, Melocchi, Valentina, Viel, Alessandra, Basso, Gianluca, Laghi, Luigi, Caselle, Michele, Ciccarelli, Francesca D
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4181412/
https://ncbi.nlm.nih.gov/pubmed/25175524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0437-8
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