Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Synchronous colorectal cancers (syCRCs) are physically separated tumours that develop simultaneously. To understand how the genetic and environmental background influences the development of multiple tumours, here we conduct a comparative analysis of 20 syCRCs from 10 patients. We show that syCRCs h...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cereda, Matteo, Gambardella, Gennaro, Benedetti, Lorena, Iannelli, Fabio, Patel, Dominic, Basso, Gianluca, Guerra, Rosalinda F., Mourikis, Thanos P., Puccio, Ignazio, Sinha, Shruti, Laghi, Luigi, Spencer, Jo, Rodriguez-Justo, Manuel, Ciccarelli, Francesca D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935966/
https://ncbi.nlm.nih.gov/pubmed/27377421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12072
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