Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

Many synthetic polycationic vectors for non-viral gene delivery show high efficiency in vitro, but their usually excessive charge density makes them toxic for in vivo applications. Here we describe the synthesis of a series of high molecular weight terpolymers with low charge density, and show that...

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Bibliografiske detaljer
Main Authors: Zhou, Jiangbing, Liu, Jie, Cheng, Christopher J., Patel, Toral R., Weller, Caroline E., Piepmeier, Joseph M., Jiang, Zhaozhong, Saltzman, W. Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180913/
https://ncbi.nlm.nih.gov/pubmed/22138789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3187
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