SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHOG-GLI (HH-GLI) signaling is required for melanoma growth and for survival and expansion of...

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Bibliographische Detailangaben
Hauptverfasser: Santini, R, Pietrobono, S, Pandolfi, S, Montagnani, V, D'Amico, M, Penachioni, J Y, Vinci, M C, Borgognoni, L, Stecca, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180644/
https://ncbi.nlm.nih.gov/pubmed/24681955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.71
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