Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway

We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor β (TGFβ) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potenti...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lee, I H, Sohn, M, Lim, H J, Yoon, S, Oh, H, Shin, S, Shin, J H, Oh, S-H, Kim, J, Lee, D K, Noh, D Y, Bae, D S, Seong, J K, Bae, Y S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180639/
https://ncbi.nlm.nih.gov/pubmed/24662814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.69
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky