Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway

We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor β (TGFβ) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potenti...

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Main Authors: Lee, I H, Sohn, M, Lim, H J, Yoon, S, Oh, H, Shin, S, Shin, J H, Oh, S-H, Kim, J, Lee, D K, Noh, D Y, Bae, D S, Seong, J K, Bae, Y S
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180639/
https://ncbi.nlm.nih.gov/pubmed/24662814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.69
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