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Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway
We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor β (TGFβ) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potenti...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180639/ https://ncbi.nlm.nih.gov/pubmed/24662814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.69 |
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