Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

BACKGROUND: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. RESULTS: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who...

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Main Authors: Ritchie, Adam John, Cai, Fangping, Smith, Nicola MG, Chen, Sheri, Song, Hongshuo, Brackenridge, Simon, Abdool Karim, Salim S, Korber, Bette T, McMichael, Andrew J, Gao, Feng, Goonetilleke, Nilu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180588/
https://ncbi.nlm.nih.gov/pubmed/25212771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0069-9
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