Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund’s adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats

BACKGROUND: Intraplantar administration of complete Freund's adjuvant (CFA) and formalin are two noxious stimuli commonly used to produce sustained pain-related behaviors in rodents for research on neurobiology and treatment of pain. One clinically relevant manifestation of pain is depression o...

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Detalhes bibliográficos
Main Authors: Leitl, Michael D, Potter, David N, Cheng, Kejun, Rice, Kenner C, Carlezon, William A, Negus, S Stevens
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180532/
https://ncbi.nlm.nih.gov/pubmed/25245060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-62
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