Pain-Related Depression of the Mesolimbic Dopamine System in Rats: Expression, Blockade by Analgesics, and Role of Endogenous κ-opioids

Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment. This study tested the hypothesis that pain-related behavioral depression is mediated by activation of endogenous κ-opioid systems and subsequent depression of mesolimbi...

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Autors principals: Leitl, Michael D, Onvani, Sara, Bowers, M Scott, Cheng, Kejun, Rice, Kenner C, Carlezon, William A, Banks, Matthew L, Negus, S Stevens
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895239/
https://ncbi.nlm.nih.gov/pubmed/24008352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.236
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