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Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats

κ Opioid receptor agonists that do not readily cross the blood-brain barrier are peripherally restricted and distribute poorly to the central nervous system after systemic administration. Peripherally restricted κ agonists have promise as candidate analgesics, because they may produce antinociceptio...

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Detalhes bibliográficos
Main Authors: Negus, S. Stevens, O'Connell, Robert, Morrissey, Ember, Cheng, Kejun, Rice, Kenner C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286312/
https://ncbi.nlm.nih.gov/pubmed/22128346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.186783
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