Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methane (C-DIM) compounds exhibit antineoplastic activity in multiple cancer cell lines and the p-hydroxyphenyl analog (DIM-C-pPhOH) inactivates nuclear receptor 4A1 (NR4A1) in lung and pancreatic cancer cell lines. Using a series of 14 different p-substit...

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Detalhes bibliográficos
Main Authors: Lee, Syng-Ook, Li, Xi, Hedrick, Erik, Jin, Un-Ho, Tjalkens, Ronald B., Backos, Donald S., Li, Li, Zhang, Yi, Wu, Qiao, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179635/
https://ncbi.nlm.nih.gov/pubmed/25099012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1102
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