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STRUCTURE-DEPENDENT ACTIVATION OF NR4A2 (Nurr1) BY 1,1-BIS(3′-INDOLYL)-1-(AROMATIC)METHANE ANALOGS IN PANCREATIC CANCER CELLS

NR4A2 (Nurr 1) is an orphan nuclear receptor with no known endogenous ligands and is highly expressed in many cancer cell lines including Panc1 and Panc28 pancreatic cancer cells. Structure-dependent activation of NR4A2 by a series of 1,1-bis(3′-indolyl)-1-(aromatic)methane (C-DIM) analogs was deter...

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書目詳細資料
Main Authors: Li, Xi, Lee, Syng-Ook, Safe, Stephen
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408083/
https://ncbi.nlm.nih.gov/pubmed/22405837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.02.021
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