Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma

The orphan nuclear receptor NR4A1 exhibits pro-oncogenic activity in cancer cell lines. NR4A1 activates mTOR signaling, regulates genes such as thioredoxin domain containing 5 and isocitrate dehydrogenase 1 that maintain low oxidative stress, and coactivates specificity protein 1 (Sp1)-regulated pro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Hedrick, Erik, Lee, Syng-Ook, Kim, Gyungeun, Abdelrahim, Maen, Jin, Un-Ho, Safe, Stephen, Abudayyeh, Ala
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452731/
https://ncbi.nlm.nih.gov/pubmed/26035713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128308
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