Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

The spindle assembly checkpoint (SAC) is a surveillance mechanism monitoring cell cycle progression, thus ensuring accurate chromosome segregation. The conserved mitotic kinase Mps1 is a key component of the SAC. The human Mps1 exhibits comprehensive phosphorylation during mitosis. However, the rela...

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Bibliographic Details
Main Authors: Wang, Xinghui, Yu, Huijuan, Xu, Leilei, Zhu, Tongge, Zheng, Fan, Fu, Chuanhai, Wang, Zhiyong, Dou, Zhen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179234/
https://ncbi.nlm.nih.gov/pubmed/25265012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104723
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