Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores

Accurate mitosis depends on a surveillance system called the spindle assembly checkpoint. This checkpoint acts at kinetochores, which attach chromosomes to the dynamic tips of spindle microtubules. When a kinetochore is unattached or improperly attached, the protein kinase Mps1 phosphorylates kineto...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Koch, Lori B., Opoku, Kwaku N., Deng, Yi, Barber, Adrienne, Littleton, Aimee J., London, Nitobe, Biggins, Sue, Asbury, Charles L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717314/
https://ncbi.nlm.nih.gov/pubmed/31405987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901653116
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