Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Previous studies have shown that human immunodeficiency virus (HIV) protease cleaves procaspase 8 to a fragment, termed Casp8p41, that lacks caspase activity but nonetheless contributes to T cell apoptosis. Herein, we show that Casp8p41 contains a domain that interacts with the BH3-binding groove of...

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Détails bibliographiques
Auteurs principaux: Sainski, Amy M., Dai, Haiming, Natesampillai, Sekar, Pang, Yuan-Ping, Bren, Gary D., Cummins, Nathan W., Correia, Cristina, Meng, X. Wei, Tarara, James E., Ramirez-Alvarado, Marina, Katzmann, David J., Ochsenbauer, Christina, Kappes, John C., Kaufmann, Scott H., Badley, Andrew D.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178959/
https://ncbi.nlm.nih.gov/pubmed/25246614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405051
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