HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome

HIV protease is known to cause cell death, which is dependent upon cleavage of procaspase 8. HIV protease cleavage of procaspase 8 generates Casp8p41, which directly binds Bak with nanomolar affinity, causing Bak activation and consequent cell death. Casp8p41 can also bind Bcl2 with nanomolar affini...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Virol
मुख्य लेखकों: Natesampillai, Sekar, Cummins, Nathan W., Nie, Zilin, Sampath, Rahul, Baker, Jason V., Henry, Keith, Pinzone, Marilia, O'Doherty, Una, Polley, Eric C., Bren, Gary D., Katzmann, David J., Badley, Andrew D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2018
विषय:
Vaccines and Antiviral Agents
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002723/
https://ncbi.nlm.nih.gov/pubmed/29643240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00037-18
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