HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome

HIV protease is known to cause cell death, which is dependent upon cleavage of procaspase 8. HIV protease cleavage of procaspase 8 generates Casp8p41, which directly binds Bak with nanomolar affinity, causing Bak activation and consequent cell death. Casp8p41 can also bind Bcl2 with nanomolar affini...

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Vydáno v:J Virol
Hlavní autoři: Natesampillai, Sekar, Cummins, Nathan W., Nie, Zilin, Sampath, Rahul, Baker, Jason V., Henry, Keith, Pinzone, Marilia, O'Doherty, Una, Polley, Eric C., Bren, Gary D., Katzmann, David J., Badley, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002723/
https://ncbi.nlm.nih.gov/pubmed/29643240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00037-18
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