The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak

Casp8p41, a novel protein generated when HIV-1 protease cleaves caspase 8, independently causes NF-κB activation, proinflammatory cytokine production, and cell death. Here we investigate the mechanism by which Casp8p41 induces cell death. Immunogold staining and electron microscopy demonstrate that...

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Detalhes bibliográficos
Main Authors: Sainski, Amy M., Natesampillai, Sekar, Cummins, Nathan W., Bren, Gary D., Taylor, Julie, Saenz, Dyana T., Poeschla, Eric M., Badley, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147983/
https://ncbi.nlm.nih.gov/pubmed/21653671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02515-10
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