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The Phosphatidylinositol 3-Kinase (PI3K) Isoform Dependence of Tumor Formation Is Determined by the Genetic Mode of PI3K Pathway Activation Rather than by Tissue Type

Previous work has shown that prostate cancer in a Pten-null murine model is dependent on the p110β isoform of phosphatidylinositol 3-kinase (PI3K), while breast cancer driven by either polyoma middle T antigen (MT) or HER2 is p110α dependent. Whether these differences in isoform dependence arise fro...

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Main Authors: Utermark, Tamara, Schmit, Fabienne, Lee, Sang Hyun, Gao, Xueliang, Schaffhausen, Brian S., Roberts, Thomas M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178865/
https://ncbi.nlm.nih.gov/pubmed/24991009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01409-14
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