Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation

Jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus (ENTV) are simple betaretroviruses that cause epithelial cell tumors in the lower and upper airways of sheep and goats. The envelope (Env) glycoproteins of both viruses can transform rodent and chicken fibroblasts, indicating that the...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Liu, Shan-Lu, Lerman, Michael I., Miller, A. Dusty
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Transformation and Oncogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12829832/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.14.7924-7935.2003
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