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Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation

Jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus (ENTV) are simple betaretroviruses that cause epithelial cell tumors in the lower and upper airways of sheep and goats. The envelope (Env) glycoproteins of both viruses can transform rodent and chicken fibroblasts, indicating that the...

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Publicado en:J Virol
Autores principales: Liu, Shan-Lu, Lerman, Michael I., Miller, A. Dusty
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2003
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161958/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12829832/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.14.7924-7935.2003
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