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Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
Passage of hepatitis C virus (HCV) in human hepatoma cells resulted in populations that displayed partial resistance to alpha interferon (IFN-α), telaprevir, daclatasvir, cyclosporine, and ribavirin, despite no prior exposure to these drugs. Mutant spectrum analyses and kinetics of virus production...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4178724/ https://ncbi.nlm.nih.gov/pubmed/25122776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01860-14 |
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