Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus

Passage of hepatitis C virus (HCV) in human hepatoma cells resulted in populations that displayed partial resistance to alpha interferon (IFN-α), telaprevir, daclatasvir, cyclosporine, and ribavirin, despite no prior exposure to these drugs. Mutant spectrum analyses and kinetics of virus production...

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Main Authors: Sheldon, Julie, Beach, Nathan M., Moreno, Elena, Gallego, Isabel, Piñeiro, David, Martínez-Salas, Encarnación, Gregori, Josep, Quer, Josep, Esteban, Juan Ignacio, Rice, Charles M., Domingo, Esteban, Perales, Celia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Genetic Diversity and Evolution
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178724/
https://ncbi.nlm.nih.gov/pubmed/25122776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01860-14
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