Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial

BACKGROUND: Intradermal MVA85A, a candidate vaccine against tuberculosis, induces high amounts of Ag85A-specific CD4 T cells in adults who have already received the BCG vaccine, but aerosol delivery of this vaccine might offer immunological and logistical advantages. We did a phase 1 double-blind tr...

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Detalhes bibliográficos
Main Authors: Satti, Iman, Meyer, Joel, Harris, Stephanie A, Thomas, Zita-Rose Manjaly, Griffiths, Kristin, Antrobus, Richard D, Rowland, Rosalind, Ramon, Raquel Lopez, Smith, Mary, Sheehan, Sharon, Bettinson, Henry, McShane, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science ;, The Lancet Pub. Group 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178237/
https://ncbi.nlm.nih.gov/pubmed/25151225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(14)70845-X
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