Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

BACKGROUND: TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechani...

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Κύριοι συγγραφείς: Takakusagi, Yoichi, Matsumoto, Shingo, Saito, Keita, Matsuo, Masayuki, Kishimoto, Shun, Wojtkowiak, Jonathan W., DeGraff, William, Kesarwala, Aparna H., Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Munasinghe, Jeeva P., Gillies, Robert J., Mitchell, James B., Hart, Charles P., Krishna, Murali C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177858/
https://ncbi.nlm.nih.gov/pubmed/25254649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107995
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