Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

BACKGROUND: TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechani...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Takakusagi, Yoichi, Matsumoto, Shingo, Saito, Keita, Matsuo, Masayuki, Kishimoto, Shun, Wojtkowiak, Jonathan W., DeGraff, William, Kesarwala, Aparna H., Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Munasinghe, Jeeva P., Gillies, Robert J., Mitchell, James B., Hart, Charles P., Krishna, Murali C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177858/
https://ncbi.nlm.nih.gov/pubmed/25254649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107995
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