Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

BACKGROUND: TH-302 is a hypoxia-activated prodrug (HAP) of bromo isophosphoramide mustard that is selectively activated within hypoxic regions in solid tumors. Our recent study showed that intravenously administered bolus pyruvate can transiently induce hypoxia in tumors. We investigated the mechani...

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Detalhes bibliográficos
Main Authors: Takakusagi, Yoichi, Matsumoto, Shingo, Saito, Keita, Matsuo, Masayuki, Kishimoto, Shun, Wojtkowiak, Jonathan W., DeGraff, William, Kesarwala, Aparna H., Choudhuri, Rajani, Devasahayam, Nallathamby, Subramanian, Sankaran, Munasinghe, Jeeva P., Gillies, Robert J., Mitchell, James B., Hart, Charles P., Krishna, Murali C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177858/
https://ncbi.nlm.nih.gov/pubmed/25254649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107995
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