Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

BACKGROUND: Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a. METHODS: We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. RESULTS: Rb1...

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Detalhes bibliográficos
Main Authors: Kikuchi, Ken, Taniguchi, Eri, Chen, Hung-I Harry, Svalina, Matthew N, Abraham, Jinu, Huang, Elaine T, Nishijo, Koichi, Davis, Sean, Louden, Christopher, Zarzabal, Lee Ann, Recht, Olivia, Bajwa, Ayeza, Berlow, Noah, Suelves, Mònica, Perkins, Sherrie L, Meltzer, Paul S, Mansoor, Atiya, Michalek, Joel E, Chen, Yidong, Rubin, Brian P, Keller, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177545/
https://ncbi.nlm.nih.gov/pubmed/24274149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-3-27
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