Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

BACKGROUND: Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a. METHODS: We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. RESULTS: Rb1...

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Détails bibliographiques
Auteurs principaux: Kikuchi, Ken, Taniguchi, Eri, Chen, Hung-I Harry, Svalina, Matthew N, Abraham, Jinu, Huang, Elaine T, Nishijo, Koichi, Davis, Sean, Louden, Christopher, Zarzabal, Lee Ann, Recht, Olivia, Bajwa, Ayeza, Berlow, Noah, Suelves, Mònica, Perkins, Sherrie L, Meltzer, Paul S, Mansoor, Atiya, Michalek, Joel E, Chen, Yidong, Rubin, Brian P, Keller, Charles
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177545/
https://ncbi.nlm.nih.gov/pubmed/24274149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-3-27
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