Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

BACKGROUND: Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a. METHODS: We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models. RESULTS: Rb1...

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Hauptverfasser: Kikuchi, Ken, Taniguchi, Eri, Chen, Hung-I Harry, Svalina, Matthew N, Abraham, Jinu, Huang, Elaine T, Nishijo, Koichi, Davis, Sean, Louden, Christopher, Zarzabal, Lee Ann, Recht, Olivia, Bajwa, Ayeza, Berlow, Noah, Suelves, Mònica, Perkins, Sherrie L, Meltzer, Paul S, Mansoor, Atiya, Michalek, Joel E, Chen, Yidong, Rubin, Brian P, Keller, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177545/
https://ncbi.nlm.nih.gov/pubmed/24274149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-3-27
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